xCEBRA Time Schizophrenia

xCEBRA-Time

This repository contains notebooks for running xCEBRA-based analyses and figure generation for schizophrenia time-series experiments. See our manuscript: “An explainable AI latent space of brain dynamics reveals a cerebello-prefrontal signature of schizophrenia symptoms” Moritz Bonhoeffer, Paolo Muratore, Mackenzie Weygandt Mathis & Indrit Bègue.

Repository contents

• xCEBRA_combined.ipynb — main xCEBRA workflow.
• Ensemble_xCEBRA_models.ipynb — ensemble modeling workflow.
• Decode_clinical_variables_different_decoders.ipynb — decoder comparison for clinical variables.
• Data_Pipeline_for_publishing/ — preprocessing and atlas/time-course preparation notebooks.
• Plotting_for_figures/ — plotting notebooks and generated figures.

Easy run instructions

Option A: Run locally with Python

1. Create and activate a virtual environment:
   • python -m venv .venv
   • source .venv/bin/activate (Linux/macOS) or .venv\\Scripts\\activate (Windows)
2. Install dependencies (see below):
   • pip install -r requirements.txt
3. Start Jupyter:
   • jupyter notebook
4. Open notebooks in this recommended order:
   • Data_Pipeline_for_publishing/*.ipynb
   • xCEBRA_combined.ipynb
   • Ensemble_xCEBRA_models.ipynb
   • Decode_clinical_variables_different_decoders.ipynb
   • Plotting_for_figures/*.ipynb

Option B: Run with Docker

1. Build:
   • docker build -t xcebra-schizophrenia .
2. Run:
   • docker run --rm -p 8888:8888 -v "$PWD":/workspace xcebra-schizophrenia
3. Open Jupyter in your browser at the URL shown in the container output.

Required Software Stack

Install all dependencies:

pip install -r requirements.txt

Primary runtime stack:

• Python 3.10
• PyTorch (torch)
• CEBRA (cebra)
• Scientific stack: numpy, pandas, scipy, scikit-learn
• Neuroimaging stack: nibabel, nilearn, SUITPy
• Plotting: matplotlib, seaborn
• Utilities used in notebooks: joblib, pingouin, openpyxl
• Notebook tools: notebook, ipykernel

Dependency graph

flowchart TD
    NB[Notebooks in this repo] --> CORE[torch + cebra]
    NB --> SCI[numpy + pandas + scipy + scikit-learn]
    NB --> NEURO[nibabel + nilearn + SUITPy]
    NB --> PLOT[matplotlib + seaborn]
    NB --> UTIL[joblib + pingouin + openpyxl]

View notebooks with Jupyter Book

This repo includes Jupyter Book configuration files:

• _config.yml
• _toc.yml

To build and serve the book locally:

1. Install Jupyter Book:
   • pip install jupyter-book
2. Build the site from the repository root:
   • jupyter-book build .
3. Open:
   • _build/html/index.html

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